CONTRAST MEDIA RESEARCH SYMPOSIUM 2007
October 16-20, 2007
– Banff, Canada
PROGRAM
Tuesday,
October 16
16:00-18:00
Registration
18:00-20:00
Welcome Reception
At
Leisure Dinner (Hotel
Restaurants)
Wednesday,
October 17
7:00-8:30
Breakfast (D.C.
Coleman)
7:30-8:30
Registration
8:20-8:30
Welcome and Announcements
8:30-10:00
SESSION 1: ISCHEMIA, INFLAMMATION, AND NECROSIS (Shaughnessy/Beatty)
Moderators: Y. Ni & V. Desestret
- V.
Desestret:
Early stages investigation of USPIO-induced signal loss after focal
cerebral ischemia in mice
- J.
Marsh:
Potential of streptokinase-activated nanoparticles for early
revascularization in acute ischemic stroke
- P.
Caravan:
Molecular MR imaging of myocardial collagen and assessment of
myocardial perfusion
- E.
Canet-Soulas:
In-vivo USPIO’s follow-up and optimized MRI protocol for
inflammation imaging in atherosclerotic plaques
- C.
Corot:
MMP-targeted Gd chelate for atherosclerotic imaging: experimental
proof of concept
- Y.
Ni:
Necrosis avid contrast agents (NACAs): evidence in favor of
hypothetical mechanisms and new potential applications
10:00-10:30
Coffee Break
(Shaughnessy/Beatty)
10:30-12:00
SESSION 2: MICROVASCULAR AND LYMPHATIC IMAGING
(Shaughnessy/Beatty)
Moderators: R. Brasch & R. Pollard
- C.
Cuenod:
Unified theory of pharmacokinetic modeling for measuring the
microvascular parameters using DCE-MRI and DCE-CT
- R.
Brasch:
Characterizing cancer microvasculature: correlations of dynamic
macromolecular contrast media (MMCM)-enhanced MRI with microscopic
morphology
- L.
Fournier:
Can clinical DCE-CT using small molecular iodinated contrast agent
detect and quantify the effect of anti-angiogenic drugs on metastatic
renal cell carcinoma?
- B.
Yeh:
Novel macromolecular iodinated contrast medium permits assays of
cancer microvascular leakiness in response to anti-VEGF antibody
using dynamic CT
- D.R.
Vera:
Lymphoseek: a molecular imaging agent for sentinel node mapping of
melanoma, breast, and gastrointestinal cancers
- H.
Kobayashi:
A multi-modal and multi-color dendrimer-based nano-sized contrast
agent for near infrared optical and radionuclide lymphatic imaging
12:00-13:30
Lunch (Mt.
Stephen Hall)
13:30-14:45
SESSION 3: TUMOR IMAGING (PART 1) (Shaughnessy/Beatty)
Moderators: J. Weichert & H. Daldrup-Link
- E.
Wisner:
Targeted imaging of canine and human lymphomes
- J.J.
Fütterer:
Detection of local recurrence of prostate cancer using dynamic
contrast enhanced MR imaging and MR guided biopsy at 3 Tesla
- M.
Essig:
Gadovosvested trisodium (Vasovist®) – initial
experience in
brain tumor imaging
- V.M.
Runge:
Gadolinium chelate enhanced imaging at 1.5 and 3 T in a rat brain
glioma model, using matched gradients and receiver coils, comparing
SE, 2D and 3D GRE, and 3D MP-RAGE techniques
- G.
Le Duc:
Use of a Gd-chelate as a dose enhancement agent for synchrotron
microbeam radiation therapy applied to rodent brain tumors
14:45-15:15
Coffee Break
(Shaughnessy/Beatty)
15:15-16:45
SESSION 4: TUMOR IMAGING (PART 2) (Shaughnessy/Beatty)
Moderators: V.M. Runge & J.J. Fütterer
- J.
Weichert:
NM 404 cancer imaging
- J.S.
Josan:
A novel targeting approach to molecular imaging based on
heteromultivalency
- J.
Sutcliffe:
High-throughput in vivo screening of targeted molecular imaging
agents using PET
- S.
Hausner:
Improved molecular imaging probe for in vivo detection of the
integrin αvβ6
- H.
Daldrup-Link:
MR imaging of breast and ovarian cancers with folate-receptor
targeted contrast agents
- C. Riedl:
Optical hemoglobin-based molecular imaging of the female breast:
imaging characteristics of human breast lesions with CT laser
mammography (CTLM)
At
Leisure Dinner (Hotel
Restaurants)
Thursday,
October 18
7:00-8:30
Breakfast (D.C.
Coleman)
8:30-9:30
HARRY FISCHER MEMORIAL LECTURE — Robert Mattrey (Shaughnessy/Beatty)
9:30-10:15
SESSION 5: ULTRASOUND AGENTS (PART 1) (Shaughnessy/Beatty)
Moderators: A. Klibanov
- P.A.
Dayton:
Optimizing the size distribution of contrast agents for ultrasound
imaging
- R.
Mattrey:
Effect of ultrasound imaging on cells labeled with microbubbles
- D.
Simberg:
Interactions between microbubbles and blood cells
10:15-10:45
Coffee Break
(Shaughnessy/Beatty)
10:45-12:00
SESSION 6: ULTRASOUND AGENTS (PART 2) (Shaughnessy/Beatty)
Moderators: R. Mattrey & P. Dayton
- M.
Schneider:
Angiogenic molecular imaging with KDR-targeted microbubbles
- A.
Klibanov:
Targeted ultrasound contrast imaging of tumor vasculature markers
- R.
Pollard:
Contrast enhanced destruction--replenishment CPS ultrasound for
quantifying cortical and medullary blood flow in a rat kidney model
- R.
Pollard:
Contrast enhanced CPS ultrasound for quantifying response to
vasoactive drugs in a rat kidney model
12:00-13:30
Lunch (Mt.
Stephen Hall)
13:30-15:15
SESSION 7: MACROMOLECULAR AND PARTICULATE AGENTS
(Shaughnessy/Beatty)
Moderators: R. Muller & M. Poirer-Quinot
- Y.
Fu:
Development of new dendrimeric MRI contrast agents with poly(ethylene
glycol) cores: toward the selection of the single best compound
- E.
Wiener:
A novel fluorinated dendrimer-based nanotechnology platform for
molecular and cellular imaging with 19F MRI
- R.
Muller:
Investigation of the structure-stability relationship of macrocyclic
and linear MRI contrast agents
- M.
Pagel:
In vivo PARACEST MRI
- S. Aime:
Gd-loaded nanosized systems for MR visualization of tumor cells
- Z.
Lu:
Biodegradable macromolecular MRI contrast agents
- J.
Bridot:
Hybrid gadolinium oxide nanoparticles: contrast agents combining
diagnosis and therapy
15:15-15:45
Coffee Break
(Shaughnessy/Beatty)
15:45-17:15
SESSION 8: NEW AGENTS, CHEMISTRY
(Shaughnessy/Beatty)
Moderators: E. Wiener & M. Pagel
- R.
Muller:
A comprehensive study of the charge-water exchange rate relationship
in a series of Gd-DTPA derivatives, potential MRI contrast agents
- S.
Laurent:
In vitro characterization of a new Gd complex and its Eu analogue,
suitable bimodal contrast agents for MRI and optical imaging
- S.
Roux:
Gold nanoparticles as contrast agents for MRI and x-ray computed
tomography imaging
- R.
Sengar:
Bifunctional AAZTA-ligand based contrast agents for molecular and
cellular imaging by MRI
- R. Rajagopalan:
Fluorescence-enhanced europium complexes for the assessment of renal function
- D.
Kraitchman:
An x-ray-visible microencapsulation method to enhance delivery and
engraftment of allogeneic stem cells for cardiovascular applications
19:00
Dinner (Mt.
Stephen/Oak)
Friday,
October 19
7:00-8:30
Breakfast (D.C.
Coleman)
8:30-9:30
Guest Speaker: Lester Crawford
(Shaughnessy/Beatty)
9:30-10:45
SESSION 9: ADVERSE REACTIONS—NSF
(Shaughnessy/Beatty)
Moderators: O. Clement & K. Hegenscheid
- H.
Thomsen:
25 Danish single center cases of NSF
- A.
Morisetti:
Gd determination in rats’ organs upon i.v. administration of
Gd-chelates and Gd-acetate
- H.
Schmitt-Willich:
NSF and Gd-containing MR contrast agents: do the different
stabilities of MR contrast agents translate into relevant differences
in-vivo?
- T.
Frenzel: :
Stability and dissociation of Gd-complexes in human serum
- M.
Sieber:
The potential role of gadolinium in the pathogenesis of NSF
10:45-11:15
Coffee Break (Shaughnessy/Beatty)
SESSION
10: SAFETY AND ADVERSE REACTIONS
(Shaughnessy/Beatty)
Moderators: H. Thomsen
11:15-11:45
E. Lasser:
Contrast media: the other side of the coin
11:45-12:15
- K.
Hegescheid:
A randomized comparison of safety, tolerance, and contrast of
intravenous iosimenol to iodixanol (Visipaque®) in patients
undergoing whole-body computed tomography
- O.
Clément:
Immediate allergic reactions to iodinated or gadolinated contrast
media. Intermediate results of the CIRTACI study, a French
prospective multicenter trial
12:15
Lunch (Mt.
Stephen Hall)
On
Your own in Banff or Surrounding Environs
At
Leisure Dinner (Hotel
Restaurants)
Saturday,
October 20
7:00-8:30
Breakfast (D.C.
Coleman)
9:00-10:30
SESSION 11: CELLULAR AND BIOMATERIALS IMAGING
(Shaughnessy/Beatty)
Moderators: J. Bulte & T. Henning
- J.
Bulte:
PFOB trimodal microcapsules for immunoprotection and visualization of
cellular therapeutics with ultrasound, CT, and MRI
- F.
Gazeau:
Cell-derived magnetic microvesicles as multifunctional vectors
- M.
Poirer-Quinot: Non-invasive
contrast-enhanced 3D high-resolution MRI of cell seeding in
biomaterial scaffolds designed for tissue engineering
- M.
Essig:
Highly effective - uptake mediating agent-free - stem cell tracking
using Gadofluorine M for magnetic resonance imaging at 1.5T: an in
vitro and in vivo study
- T.
Henning:
Chondrogenic differentiation of ferucarbotran labeled human
mesenchymal stem cells and MR imaging after implantation into
cartilage defects
- E.
Sutton:
Long-term MR signal characteristics of ferucarbotran-labeled human
mesenchymal stem cells in vitro and in vivo in arthritic joints
10:30-11:00
Coffee Break (D.C.
Coleman)
11:00-12:00
SESSION 12: NOVEL IMAGING STRATEGIES
(Shaughnessy/Beatty)
Moderators: E. Wisner
- R.
Katzberg:
Utilization of small molecular weight extracellular fluid markers,
such as MR contrast media (CM), to non-invasively acquire single
kidney glomerular filtration rate (skGFR): findings in human subjects
with a solitary kidney
- V.
Stupar:
Hyperpolarized 3He MRI: a comprehensive tool for the investigation of
lung function in physio-pathological animal models?
- M. McMahon:
Design of multi-label polypeptide MR contrast agents to be used as reporter genes
- R. Gibson:
Novel contrast protocol for visualization of intestinal tumors in a mouse transgenic model by MicroCT imaging
12:00-13:30
Lunch (Mt.
Stephen Hall)
13:30-15:00
SESSION 13: HEPATOBILIARY, GI
(Shaughnessy/Beatty)
Moderators: R. Katzberg & S. Hirohashi
- J.P.
Kühn:
Enhancement of the upper abdominal organs with the liver-specific
contrast medium Gd-EOB-DTPA
- K.
Holzapfel:
Contrast-enhanced magnetic resonance cholangiography (CE-MRC) using
Gd-EOB-DTPA (Primovist®): additional value compared to
conventional MRCP sequences
- S.
Hirohashi:
New manganese based oral contrast medium for MR
cholangiopancreatography
- A.
Keedy:
Determinants of bile duct visualization at CT cholangiography for
living potential liver donors
- B. Yeh:
Evaluation of bowel opacification by excreted intravenous biliary
contrast at CT cholangiography in healthy liver donors
- J. Peacock :
A multimodality oral contrast agent based on the KISS principal
15:30-16:30
CMR BUSINESS MEETING
(Shaughnessy/Beatty)
19:00
Dinner
(Alhambra Room/Foyer)
Sunday,
October 21
At
Leisure Breakfast (Hotel
Restaurants)